Culicidology (MOSQUITOES) Part 1 with Fhallon Ware-Gilmore 59:06

I know I usually save my secrets for the end of the episode, but I'm going to tell you my secret favorite candy. It's Reese's Peanut Butter Cup.

It's really Reese's anything. But Reese's peanut butter cups are the thing that I'm like, have I had a bad day? I get these. Have I had a good day? I get these. Chocolate, salty peanut butter, the textures. I love everything about them. Also that there's two. So I'm like, oh, I get this one for later, which is one second later. Anyway, Reese's peanut butter cups. I love you. That's all. If you're me, you can shop Reese's peanut butter cups now at a store near you. Found wherever candy is sold. And I am.

Building a portfolio with Fidelity Basket Portfolios is kind of like making a sandwich. It's as simple as picking your stocks and ETFs, sort of like your meats and other topics, and managing it as one big juicy investment. Now that's pretty good. Learn more at fidelity.com slash baskets. Investing involves risks, including risk of loss. Fidelity Brokerage Services, LLC. Member NYSC SIPC.

Oh hey, it's the day drunk lady who loves your perfume. Allie Ward, back with the episode, you don't want to want, but you know that you need it. You're just itching for it. Listen, a few things I know about you, alright? You hate mosquitoes.

You want to try to appreciate literally one thing about them if you can. Also, you want to kill them. We got you. So I have waited four years to have this very specific guest on ever since we had her on the Black AF and STEM episode in the year of our lockdown 2020. Let's revisit it. Did you know that mosquito is Spanish for little fly?

So despite my nudging and begging her every spring to talk mosquitoes, she has been a bit tied up becoming Dr. Mozzie and is now working in a postdoc for the US Centers for Disease Control. For years, I've been like, whenever you're ready, I have to be ready.

I have two mics. I got a million questions. That time is now, which we will get to. But first, just a quick thanks to everyone who sends those questions in via patreon.com slash ologies. You can become a patron for as little as a buck a month. Thank you to everyone out there getting bitten in our ologies merch from ologiesmerch.com, where we have also a tick shirt that...

boldly reads, check your crevices. We also have swimsuits you can put on your body. Thank you to everyone who is listening to our spin-off show, Smologies, which just a few weeks ago launched as its own show in its own feed. Look for this colorful new logo with a bird and a frog. That show, Smologies, is in your podcast app.

or at the link in the show notes, their shorter, entirely kid-safe, classroom-friendly episodes. Also, thanks to everyone who leaves reviews for this show, Ologies, which I read all of just hungrily, including this recent one from Jane Amonik, who listened to The Secret at the end of a recent episode and said that my having at least seven friendly spiders in my office has inspired them...

has inspired them to inch toward getting over a fear of spiders. And they were able to walk past one and this feat was so giant that it moved them to tears. Jay Demonic, I bet that spider is even happier than you are or I am. So well done. Okay, calcidology, it's a real word.

It first appeared in the book review of a tome titled Mosquitoes of New York in 1979. And the reviewer noted that Mosquitoes of New York is a great contribution to Chalcedology and will stand as a frequently cited reference for years to come. Look at that.

Right now, 44 years later, I'm citing that citation. So, Cholestrology, it's a study of mosquitoes. The word comes from the Latin for midge, their tiny cousins. And because you had so, so, so, so many very valid questions, this episode went

very long. It turned from an itty bitty single to a beast. So this first part in it, you'll become familiar with your sworn enemy, learning how they work, what they eat. You'll appreciate their beauty. Trust me, their complexity, their complexity,

hunting and their strategy and the history. And then next week, we're going to tell you how to stop them from feasting on your exposed parts. So get ready right now to learn about them. You're going to fill your ears with facts about high-pitched, sexy buzzing, their wings of wonder, what is happening with their helmouts, why it's vital to study them, why they are scarier than a shark, why

where they make their babies in your yard, why the Skeeter field needs bug nerds, why these hungry bitches want your blood in the first place, why you get bitten more than your friends. And next week, what to do about all that with medical entomologist, mosquito expert and appreciator and calcidologist, Dr. Fallon Ware Gilmore. Hi, my name is Fallon Ware Gilmore and I use the pronoun she, her.

How exciting is this for me, by the way? This is very exciting for me. I'm excited to finally be on here. I felt like we went through like a whole roller coaster of like

defend my PhD, move to Puerto Rico, and then completely forgot about what was going on. So you, you're a doctor, wear Gilmore now. Yeah, I, it's wild. Yeah, I finished up my PhD last year. I just, I saw a Facebook memories post and it was like me getting, I had just picked up my cap and gown today, which is truly wild. Oh,

How exciting. I mean, I have been just kind of waiting in the mosquito wings for timing to be right for you. And now you're working with the CDC. Can you tell me a little bit about what the last year has been like for you?

Yeah, so I defended my PhD in February. And then that July, I started in a program called the Epidemic Intelligence Service. And so this is a fellowship program with the CDC, globally recognized, like was my dream position for its investigative and emergency response efforts.

So again, EIS is the United States Epidemic Intelligence Service. Did you know that existed? Neither did I. It's a two-year postdoc after PhD program for people in the health industry to do applied epidemiology. And if you're accepted into the Epidemic Intelligence Service program, you're training under CDC mentors. You're helping protect people all over the globe from some emerging and existing diseases. Also, you're

It may involve a one-way plane ticket for those who love adventure or hate their hometowns. We're sent out where we are needed globally for health care and public health support. So I am assigned to the Puerto Rico Department of Health, and it's been great. The process is

Forgetting here was a little bit bumpy, but being able to live in Puerto Rico and really immerse myself in the culture and interact with the people has been very eye-opening and just a great experience overall.

And then do you know where you might go after that? Or is it really kind of outbreak dependent or lab dependent? It's honestly dependent. You know, ideally, some officers stay with CDC. Some officers stay with the Department of Health. But you also have officers that go to farm. They go to other industries. Maybe they go back to clinical work. So it really just depends on what is available at the time and what might catch my interest.

And you mentioned something about this being a dream for you. How long have you wanted to work in mosquitoes or epidemiology or field work? Like how long has this kind of been like on your vision board? Yeah. So I, I'm going to be honest. I started out undergrad as a marine biology major and that just wasn't for me. Oh, thank you.

What about it? Do you get seasick? No. So we went, it was an ecology trip and we were in like a salt marsh. And I just was like, I don't think I can do this long term. I was freaking out. I got so stuck in the mud that my shoes got lost. So I continued walking in the salt marsh.

without any shoes. And I went to my supervisor the next week and I said, I think I need to change my major. And so it was wild because I feel like I grew up and I was like, I want to work with whales and dolphins. And then I was like, I think I'll do environmental science.

And so I took up environmental science and I had the opportunity to do some internships that were entomology focused. So studying insects and many of those were agriculture focused. So working on honeybees. But then I also did some work with wolf spiders. Wow.

Yeah, that was a fun internship. That's awesome. I never thought about, I never thought I would work with spiders or be okay with it. My mom was not okay with it. Are you pretty okay with spiders now? I love them. I actually had a pet tarantula. Her name was Rosie. She passed away a few years ago, but she was the first spider, first arachnid that I got after my internship. So they're cute up close. What was her name again? Rosie. Rosie.

What species was she? She was a rose hair tarantula. That's what I figured. I was like a pink toad or a rose hair. Yeah, she was so cute. She was the cutest little thing. So you were working in entomology and you're digging spiders. And then how did did you get the bug bug?

I did. I was like, at that point, I was doing environmental toxicology and science. And for me, it was like this was a public health service. So I was working with aquatic microorganisms to see how they could be indicators for stream and pond health.

And I was like, there's got to be a way that I can combine my interest of public health, but also of entomology. And I learned at a conference that I could do that through medical entomology. And so my friend, Shelly Whitehead. Thanks again, Shelly. Was the one who introduced me to medical entomology at the Tropical Medicine Conference, ASTMH.

And when I got home for conference, I Googled it. I looked it all up. I was like, this is what I want to do. And I applied for labs that had a medical entomology focus. Most of them were focusing on mosquito-borne diseases. And that's how I got into it. And I fell in love with it from day one. It's truly just, they're such small little critters, but they're so complicated and

I think the roles that they have in our ecosystem is very interesting. And they're beautiful up close. Like I know, you know, most people would be like mosquitoes are ugly. But under a microscope, they're shiny, they're sparkly, like they're beautiful. The scales are lovely. More on mosquito glamour and miniature looks served in a moment. I trust you on that. I love that you went from literally whales to mosquitoes. Like,

You just kept narrowing down your field until you got to like a teeny tiny but very important insect. I mean, people have said that when it comes to teeny tiny mosquitoes, and I don't know if this is flim flam or not, but that they are the most dangerous animal to humans. Is that true? Or are hippos? Where are they? How much impact do mosquitoes have on us?

So I think, you know, I've also seen this paper that was kind of ranking animals as most deadly. And you would think like off the cusp that it would be lions or maybe tigers, hippos, frightening, or bears, but they actually are mosquitoes. And not only are they a nuisance, but they've been known to be able to carry a lot of these debilitating diseases such as malaria, dengue, West Nile disease.

And also at the end of the day, mosquitoes have killed more people than any other creature in the world. Even today, almost 1 million people die a year from some type of mosquito-borne disease. So it is not the mosquito itself, but it is the pathogen or the viruses and the parasites that they can transmit that are very deadly. But you kind of, it's a package deal at the end of the day, unfortunately.

A million people a year. According to various compiled sources, the roundabout figure for human mortalities by mosquitoes is roughly a million people a year. Now, also high on the list of animals that could kill you, you ready for this? Freshwater snails, also sand flies. They each transmit some parasite friends of their own. But yeah, first on the list,

by a lot is mosquitoes at a million a year, with over 200 million mosquito spread cases of malaria a year. Most of the malaria deaths occur in little kiddos under the age of five, and it's on the rise. So yes, it is correct that mosquitoes kill more people on Earth in one day than sharks have in the last century.

Sharks are like, get off my jock, leave me alone. I like fish. But between the mosquitoes and the snails lies the number two animal risk to human beings. What animal kills us less than mosquitoes but more than snails? Lions? Is it hippos? Is it raccoons with rabies? No. The number two animal-caused mortality on Earth, coming in at over half a million deaths per year, is caused by one species. It's a species of ape.

Homo sapiens, it's you. So in terms of what animal can kill you, again, first, mosquito. Secondly, a warlord or someone who's driving and texting or maybe a person you work with who was sold firearms like it was a cell phone. Well, getting back to the mosquitoes themselves, who are apparently just kind of wrong place, wrong time, really.

You said they were beautiful and shiny and shimmery. Can you explain to me what it looks like when you're looking at a mosquito through a microscope? And like what power of microscope do you need to appreciate mosquitoes in that way?

Yeah, so I was spoiled during my graduate career because our lab had these very nice microscopes and I think they're really like expensive, high quality ones. So imagine we're at a microscope and we have this petri dish and we have these mosquitoes that have been dried down or they've been knocked down with ice to kind of keep them from moving.

And so at first glance, they just like look like little black flies with long legs. They're kind of like gangly, kind of like the jack skeleton of flies. And so when you look at them close, like mosquitoes are actually distinguished by their long, slender legs and this thin body. But they also have these specialized piercing mouth parts that allow them to feed off of invertebrates and vertebrates.

Tall, lanky legs for days and bloodthirsty mouths made of razors. Jack Skellington meets anemic 90s supermodel meets Edward Scissormouth meets a horny vampire.

In addition to that, you'll see these shiny scales. And so in my head, I'm thinking about Aedes aegypti because that is a vector or a mosquito species I work on. And you'll see scales on the wings. You'll also see scales along the body in different colors like white and silver. And so that banding is what really stands out when you first see them under the microscope. And are those scales kind of like butterfly scales? Yes.

So they're similar in the sense that actually they're actually very similar. Depending on the mosquito species, the patterns are different and they might not be as shiny as they are for say for like butterflies. But for some mosquito species, we do see shinier scales, which I guess you could also think of them as fur as an easier way to approach it. Is that why some look like tiger striped and some...

have like almost bumblebee stripes. Yeah, that's the coloration pattern of their scales. And so Aedes aegypti has like those white scales that banding around its body and around its legs.

Why are they so fancy? Yeah. And there's also, there are fancier mosquitoes. Like Aedes aegypti is just one off of the top of my head, but there are like mosquito species that have blue, like sapphire color scales basically and paddles on their leg, which we think might be used for mating as a mating signal to females. Yeah.

Hello, ladies. I didn't know that there were sapphire glittery ones like that. Yeah. It's called Sabathes cyanaces. So it's a mosquito we commonly see in Central and South America. But if you look it up, I personally would name it the peacock mosquito. But if someone was like, I don't think mosquitoes are beautiful, I think they would take one look at that mosquito and it would really change their perspective. Yeah.

So yes, they can be stonin' in metallic blues and feathery legs and antennae and these glorious shimmers. And why does that even matter?

Well, if you are intimately bonding over blood with one, it's nice to know its name. So while not all mosquitoes are transmitting diseases into your organs, a few might be. So it's good to be familiar. So Aedes is a genus that can carry Zika and yellow fever. And Aedes aegypti are those beautiful, striped, like art deco, black and white, sparkly ones. They are day snackers on your flesh. Now the Culex genus tends to be a little bleh, like all beige.

kind of like a hospital waiting room. They're very common. They're called a house mosquito and they prefer to eat at night. Side note, they can also carry West Nile virus, dog heartworm and some other scaries. And if I may...

They're the least interesting to look at. Now, anopheles, these buggers carry malaria, and you can spot them by their four fashionable brown wing spots and the way that they keep their ass in the air when they're drinking you, like a mosquito doing a keg stand. And just like your junior year homecoming date, it might do that keg stand before absolutely fucking you and giving you a disease. In this case, malaria. Anopheles,

They bite at night and they kill a lot of people. Now, if you wish that there was a Facebook for mosquitoes, the closest we might have is the 2022 study, Participatory Approaches for Raising Awareness Among Subsistence Farmers in Tanzania about the Spread of Insecticide Resistance and Malaria Vectors and the Possible Link to Improper Agricultural Pesticide Use, which notes that local farmers wanted to know what these things look like, including learning that

the malaria vector Anopheles floats as a larva parallel to the water surface. And according to the study, quote, some participants referred to Aedes as being the most beautiful mosquitoes given its black body and white spots. They also referred to male mosquitoes as bearded, providing reference to their feathery antennae, just like human males. And the study quotes one 34-year-old farmer who exclaimed, oh,

Oh, now I understand that not every mosquito in my house is anopheles and can transmit malaria. There are other mosquitoes which also dominate our village. We love bug appreciation. But why these morphological stylistic differences? So according to the 2023 study, the origin of black and white coloration of the Asian tiger mosquito, calcidologists found that it might be to communicate within their species for mating and also as a predator deflection.

And I don't want to brag for 80s, but the paper uses the exact phrase, motion dazzle camouflage. Clearly, calcidologists appreciate their study species. Do you have a soft spot in your heart for mosquitoes having studied them? I do. Unfortunately, it's very... Oh, that's great. That's great. I do. And so I...

think they're really interesting. And I think it's so wild how they've kind of evolved alongside of us, especially these species that are utilizing these urban habitats. But anytime I was doing lab work, I slightly felt bad. But at the same time, I was like, mosquito eggs hatch all the time. We have plentiful mosquitoes in the lab, but they do have a soft spot for me. So I am, when people are like, should we eradicate all mosquitoes? I'm like, hold on, you know, they're

Of the 3,700 species we have, only a certain amount of them are able to transmit pathogens that are concerning for human and animals. And the rest are just, they're doing what's basic to their biology and for the ecology. Okay, so how many mosquitoes are our quiet nemeses that we don't understand, but we feel obligated to hate? We know maybe it's rash.

And that is not an itchy pun, but we must be a legion to our own skin, right? So how many are enemies? I checked into the evidence and the accusations, aka the 2023 study, Robust Network Stability of Mosquitoes and Human Pathogens of Medical Importance. And it turns out that the majority of mosquitoes are screaming from their tiny knife mouths, I'm innocent.

Only 2.5% of mosquito species are known disease spreaders. And the jury is still out on a lot of the other species, but at most it would be 9.3%.

percent, less than a tenth of mosquitoes giving you parasites. So that's good, right? Also, it's not their fault that they have baggage in the form of pathogens. And if they could quit blood and not risk being loathed and swatted and flattened by your big hands, I'm sure they would. Do all of those species use blood as like a meal or as...

I'm not sure why they use blood and we will get to that because it is a huge question. But like what are commonalities with a mosquito? Is it just the long legs? Is it the blood lust? Is it the proboscis? Like what makes a mosquito a mosquito?

So a few things. So mosquitoes are in the order Diptera, which are the order that all of our flies are grouped into. So Diptera is Greek for two wings. So it refers to the characteristic set of wings that they have on their back. That's what gives us flies.

See our amazing dipterology episode with Dr. Brian Lessard, who names flies after drag queens officially. Happy pride, by the way. Now for mosquitoes, we have a few distinctive features that make them mosquitoes. One, it's their mouth part. So mosquitoes have this elongated tube-like mouth part called the proboscis.

which they use to pierce the skin and extract blood. And this adaptation is unique to female mosquitoes because it's essential that they blood feed. That blood is necessary for egg development. In contrast, our common housefly have these sponge-like mouth parts, which they use to sponge up liquids. Ah, yes. That dipterology episode I mentioned on flies goes into greater, darker, disgusting depth of barfing and lapping it up after tasting with their feet. Let's take a quick

trip back to dipterology with Dr. Bri the Fly Guy. They do deserve some slack. They do. What about their feet? Do they taste with their feet?

Are they covered in shit all the time? Well, they have happy feet because yes, they do taste from their feet. They're impatient. Instead of waiting to get the food in their mouth and like, you know, taste it that way like we would, they like to stand in whatever they're eating and it's yes, no, do I eat it, do I not? And so what they do is if it tastes good, that's when they'll drop their proboscis, their mouth part that has a sponge at the end that saps up all the liquid.

and they actually do eat shit because shit is high in protein and other nutrients and electrolytes as well. But that's a dipterology episode. And while mosquitoes are flies, we're honing in on calcidology specifically. And according to the National Institutes of Health, yes, mosquitoes, like cow flies, can taste with their mouth, but also their feet. They love you before they even cut you. We also know that female mosquitoes...

you know, outside of requiring blood for egg development, they can utilize a variety of different feeding hosts. And so that is a few things that make mosquitoes, mosquitoes. Are some of them solely looking for frog blood and some are looking for bird blood and some are down with humans? Or are they like, if I can pierce it and suck it, I will?

So you do have mosquito species that will feed on reptiles and amphibians, and you have some that are sylvatic and prefer forested habitats where they'll find like these woodland creatures. And you have some that primarily prefer to feed off of humans. So you do have a there is a variety in what they will feed on and their host preference at the end of the day.

So according to the 2021 study, Differential Attraction in Mosquito-Human Interactions and Implications for Disease Control, some mosquitoes prefer non-humans like birds and mammals. They're zoophilic and others want mostly you and they're androphilic. But this study also found that if their preferred meal is not available,

They'll take their second or third option, like ordering a patty melt when the diner is 86 on Rubens. But sometimes it's not even a goopy bird or a squirrel they want. There was this 2018 study, identification of Uranotania safarina as a specialist of annelids broadens known mosquito host use patterns. And it explains that, quote, despite over a century of intensive study, no mosquito species is known to specialize on non-vertebrate hosts.

However, they continue, we provide the first evidence to our knowledge that a mosquito, in this case, Eurytenia safarina, a gorgeously blue-flecked creature, specializes on earthworms and leeches. I mean, I have friends who only drink biodynamic natural wines. I have others who would happily enjoy a room-temperature gin out of a solo cup. I'm simply saying that life finds a way.

I wonder how the proboscis must be able to pierce reptile skin. Do they go in between the scales? Do they just get up in there? So the proboscis is...

strong-ish, but reptile skin is hard. So I've seen videos where they've recorded the mosquito host seeking and the mosquito found like a little tiny slither of skin where a scale wasn't covering it or the softest part of the body of that animal. So sometimes that's the stomach area that's easier for them to bite or maybe that might be near some other orifices. You know, I think that happened to my daughter, Gremie.

a dog who has a mosquito, looks like a mosquito bite right on her tummy, but you know, where she has less fur. Is that what happens to mammals too? Is it easier to bite, you know, under the legs or somewhere where it's more vulnerable? Yes. Similarly, when we go outside, typically when we're, you know, hiking or doing like a lot of outdoor activities to protect ourselves from mosquitoes, we might wear long sleeve clothing and socks, but

mosquitoes will find those spots that are not covered that are most vulnerable. And so with domestic animals like cats and dogs, it's easy to go for areas where there isn't a lot of fur. So that's going to be the facial area, maybe around the eyes, but also under the tummy. And I've also seen my dog used to get a lot of bug bites near her ear as well. Gotcha.

Yeah. I'm from California. And I remember I went to like Minnesota for a wedding once in the summer and the air was just thick with mosquitoes. I'd never seen anything like it because I'm from like a more arid climate. And I had been bending over, like doing something, helping out or whatever. And I had like a belt of mosquito web.

from like where my shirt had like come up. They don't care. But where, where, where on your body is safe? I asked the 2022 study, observing the distribution of mosquito bites on humans to inform personal protection measures against malaria and dengue vectors.

which somehow convinced four volunteers to get in a room with lab-reared and disease-free but starving mosquitoes from either 6 a.m. to noon for day-biting Aedes or 6 p.m. to midnight for night-biting Anopheles for 20 days.

And from this blood sacrifice, we now know that the Anopheles bites, when the volunteer was standing up, those were almost all below the knee. Anopheles, they like below the knee. But when these generous volunteers were lying down sleeping, they got bitten all over their damn body by the Anopheles, which are night biters. Now, the day biting, 80s bites, were almost all below the knee.

were only about 50% below the knees. And then they were all over the place while sleeping. So researchers concluded that wearing socks, trousers, and long sleeve shirts could theoretically prevent up to 83% of bites during sleeping and at least 90% of non-sleeping bites.

I also was like, OK, that's good. But I scanned the entire paper for some explanation of how they convinced people to participate in the study. And I came up blank, other than the fact that these folks were in Tanzania and they had a vested interest, perhaps, in donating their money.

fragile skin and blood to science for malarial prevention. Since they didn't get paid for their service, I'm going to read from the study acknowledgements, which include, we would like to express our sincere gratitude to our volunteers, Moses Mlegani, Boniface Maguila, Baraka Kidwanga, and Ibrahim Mikskaya. From me, thank you, sirs, for withstanding that lion's den of tiny predators.

Yeah, they're ruthless. They're ruthless, but they're smart. And maybe I smell delicious. We'll get to that too. But do they live everywhere and there's just more of them in more humid climates? Or do we just like straight up not see them in Antarctica? Yeah.

So mosquitoes are, what makes them really interesting is that they can take up a lot of these ecological niches. So they're ubiquitous in many parts of the world and their distribution at the end of the day is going to be influenced by environmental conditions and the availability of suitable breeding sites. So how good is the vibe? Can you mate? Can you lay eggs there? For the most part, yes.

most places will do, Dr. Ware-Gilmore says. So we've seen mosquitoes thrive in habitats, including temperate rainforest, tropical rainforest, urban areas. But again, you know, we're not seeing mosquitoes in Antarctica, but we are seeing them in a lot of different places. And when we have changes in climate as well, it's creating more suitable habitat for these populations to shift.

It's getting hot. Oh, right. Like right now, we might not be seeing them in the top of a Nordic fjord, but give it a couple decades and who knows? Maybe there'll be a sandals resort there. Oh, yeah. And their logo would be like a mosquito. Yeah.

Everything's changing. It is. What about the temperature? How much does the temperature affect that? And do they all just die in the winter? What happens to them? Yeah. So not all species of mosquito die in the winter. You have some species that will overwinter. So they'll overwinter as eggs or they might overwinter as larvae depending on where they are. So if you have a thick level of ice or

something that might basically be incubating them or allowing them to be dormant, that might change. So not all mosquito species die during the winter. So yes, some of your summer skeeters survived the winter without a parka, mittens, no $6 latte that got cold as soon as you stepped outside. They just hunkered down under ice, tougher than you. No offense.

And then as far as temperature plays a huge role in mosquito physiology and biology. And so temperatures need to be not perfect, but just right. So you see the emergence of the larvae into pupae and the pupae into adult. I remember when I was a kid, I thought I had found a new species of animal because I looked into a bucket and saw all these tiny shrimp. And then my dad was like, those are just mosquito larvae.

Okay. No, they're very funny looking when they're at that stage. They're just like, I don't really know what you are. And there are a lot of other fly species that will lay their eggs and bodies of water and hatch. So it can be confusing on what they might actually be. Can you tell me a little bit more about that life cycle and why a female mosquito needs that blood meal? Do they need that right before they lay eggs? And the rest of the time, what are they munching on?

That's a good question. So do we want a full story of the mosquito life cycle? Of course. Okay, dude, come on. That's fun. I love it. I wish we had visuals because there's so many good, there's so many departments of health and mosquito abatement groups that have beautiful visuals that they use and outreach to describe the life stages of the mosquito. But for this, for this, I'll try and paint a picture. And so

we'll start with Aedes aegypti. This is a container breeding mosquito, so it prefers to breed in man-made containers that are left around. So in the 2015 study, Breeding Sites of Aedes aegypti, Potential Dengue Vectors in East Ethiopia, colesidologists set out to see which reservoirs of water were the most attractive to expectant mosquito moms. And first off,

rainwater only place, okay? They did not prefer to lay eggs in tap water. It's gotta be fresh, organic,

from the sky. Now, some attractive places included mud pots, old sinks, small puddles and rumpled up tarps, and neglected buckets and such. But the top spot for a Mozzie nursery? Overwhelmingly old tires. Absolutely darling, love, obsessed. And so a female who has blood fed, who has made it, will lay these eggs on the edge of the water and

And those eggs will hatch after a certain amount of time. Once they hatch, we call those larvae. This species will stay as larvae for around maybe we'll say four to six days. And again, this is dependent on temperature conditions because if temperature is higher, the pace of them hatching and also the pace of them at their larval stage might be quicker. Or if it's lower, you might have a slower developmental cycle.

Okay, different species have different parenting styles, but a lot of common mosquitoes will lay a bunch of eggs like in a raft style, kind of in a bundle. And then when the larvae are in the water, some will be underwater using little snorkel on their face, while other species like the malaria-carrying Anopheles genus is floating flat right under the water surface. But before they emerge as adults...

rising from the water to conquer the air. They go through an awkward pupa stage where they look like shrimps with big weird heads. And after larvae, we have pupae. The pupae under the microscope look like little Shrek. They're like little commas with Shrek ears.

They're funny looking. And then after the pupae, we have adults. So they'll emerge from that aquatic habitat into terrestrial adults. And then as adults, they'll mate and then continue that cycle of laying eggs, turning into larvae, turning into pupae and adults again. But

But during that, the female will need to take on a blood meal for specific biological and reproductive reasons. So they need a blood meal in order to obtain the necessary nutrients for egg development. The blood meal provides a lot of things for them. It's providing amino acids and other proteins that are essential for their yolk. And so mosquito eggs have a type of yolk protein.

And additionally, the iron obtained from the blood aids and physiological processes needed for the overall egg development. Just like a hot smoothie, chock-a-block with fat and meat bits and protein and iron. Listen, I've never had a baby out of any hole of mine, but I have been essential to growing new life on planet Earth today.

in garbage tires, and then these babies grow up and you hate them. Yeah. I mean, good for them. Good for them. I'm not mad at it. So it's just like a tasty treat before, you know, she has to do the big push. If that makes it any better. Yeah.

It does. It does. Good for her. Is she eating or he eating anything else in the interim? If she's like, okay, I'm ready to nest. I'm ready to start a family. I need a blood meal. But if she's like, I'm not quite ready yet. I'm still exploring the world.

Is she eating nectar? Is she on a water fast? Yeah, water fast. Yes. So yeah, when she's not taking a blood meal, mosquitoes, male and female, are nectar feeders. So they're going to be using these flower resources as the sugar resource to get them by. So at the end of the day, they're actually pollinators. Oh, look at that. They're just pollinating. And then when it's time to start a family...

They just borrow a little bit of iron and protein from you. Are they looking also for anything hormonal? I feel like that is maybe a source of flim flam. That has always been a complicated one for me as well. I feel like I've done a deep dive on what...

make mosquitoes attracted to you. So we know that they're picking up certain olfactory cues and visual cues from us. So that's going to be carbon dioxide or CO2, but they're also going to be picking up signals from our sweat. So there are chemicals in our sweat that they can smell that make us very attractive. Wow.

It smells amazing. Is that worse than if you're like hiking and you're breathing out a lot of carbon dioxide and your respiratory rate's higher and you're sweatier? Is this why if you're hiking like the Pacific Crest Trail or something, you're screwed?

Yeah, I mean, so they're picking up those indicators and they're using it when they're trying to basically seek out a host to feed from. So if you're breathing more because you're hiking and you're letting out more CO2, that's just giving a better signal to the mosquito to be like, oh, that might be something I could blood feed from. We're going to dive back into what makes you so attractive to mosquitoes or potentially less attractive in a minute. But first, some words from sponsors of the show who make it possible to donate to our related cause each week. And this week is...

It'll be going to the Malaria No More Foundation, which has worked for nearly two decades campaigning to end malaria and make a world where no one dies from a mosquito bite. And so far, well over 2 billion mosquito nuts have been distributed in areas hardest hit by malarial transmission and over 7 million lives have been saved. And you can find out more at malaria no more.org. And thanks to sponsors of the show for making that donation possible. When U.S. Bank says they're in it with you.

They mean it. Not just for the good stuff, the grand openings and celebrations, although those are pretty great, but for all the hard work it took to get there. The fine tuning of goals, the managing of cash and workflows, and decision making. They're in to help you through all of it.

because together they're proving day in and day out that there is nothing as powerful as the power of us. Visit usbank.com to get started today. Equal housing lender, member FDIC, copyright 2024, US Bank. This show is sponsored by BetterHelp. And as I record this, my dog, Gremmy, is snoring.

Sometimes you got to stop and smell the roses. Sometimes you got to stop and record the snoring. Even when we know what makes us happy, it's hard to make time for it. And when you feel like you have no time for yourself, non-negotiables like therapy are more important than ever. So if you were thinking of starting therapy, give BetterHelp a try. It's entirely online. It's designed to be convenient and flexible. I love everything.

that it is so quick to get a therapist. You just fill out a brief questionnaire so they can figure out what you need, what you're looking for. They match you with a licensed therapist. Boom, makes it so easy. It's more affordable than most traditional therapies. And if for any reason you are not vibing, you can switch therapists anytime for no additional charge.

I've used BetterHelp. It has helped me through some really tough stuff in my life and has really taught me to stop, let myself relax, pet my dog, go to bed early, that I'm worth those things, I deserve those things, and it'll make my life better in the long run. So never skip therapy day with BetterHelp. Visit betterhelp.com slash ologies today to get 10% off your first month. So that's betterhelp, H-E-L-P dot com slash ologies. Grammy says it's okay to nap too.

Okay, so think about your childhood and think about some highlights. I bet they were probably out essentially tinkering. This is why I love KiwiCo. Each month, they send a kid a crate. It's packed with these engaging hands-on activities. They introduce them to science and technology and art concepts.

There's always something new. They have things like engineering robots or learning about the science of ice cream. They have nine monthly programs to choose from. They have something for kids of all ages, ranging from infants and preschoolers to teens and beyond. If you have a kid, if you know a kid, this is

such a good gift for them because it can cultivate their natural curiosity all while doing things like discovering the science of magic or engineering a domino machine and more. This is why I get KiwiCo for friends, kids, for nieces, for nephews. I love that there's a ton of different types of crates to choose from. And then I love when I get like pictures and videos of the kids who are like playing with them. They're always having such a good time. So help kids make mems. Redefine learning with the

Play, explore projects that build confidence and problem-solving skills with KiwiCo. And you can get 50% off your first month on any crate line at KiwiCo.com with the promo code Ologies. So that's 50% off your first month at KiwiCo.com. Promo code is Ologies. They're going to dig it. Trust me.

Listen, we're out there. We're seeing AI images all over the internet. Someone forwarded me a picture of a centipede-like creature in the desert. And I was like, that's not a real creature. And Ritual Vitamins knows that every good skeptic deserves a multivitamin that exceeds your standards. Ritual was created by skeptics.

And they have a clinically backed essential for women 18 plus multivitamin has high quality traceable key ingredients. I know for me, I have more energy and I feel better when I'm taking my multivitamins. And I know with Ritual, I'm getting what I need and not a bunch of stuff that I don't. Only about 1% of supplement brands are USP verified and Ritual is one of them. It's also a female founded B Corp.

I've been taking Ritual for years. Grab a couple every morning. Not only are they beautiful and they look like tiny lava lamps because there's beads floating in oil, I also like that they have a minty flavor because studies have shown that if something is pleasing, you'll take it up as a habit easier. So no more shady business. Ritual's Essential for Women 18 Plus is a multivitamin you can actually trust.

Get 25% off your first month at ritual.com slash ologies. You can start Ritual or you can add Essential for Women 18 plus to your subscription today. So that's ritual.com slash ologies for 25% off. Down the hatch.

Okay, so we were talking about who gets bitten the most. And if you're wondering, do people really study that? The answer is, are you okay? Of course they do, yes. Cholestodologists are all about this question. And according to the 2021 meta study, variability in human attractiveness to mosquitoes. Mosquitoes are known to find and bite humans by being attracted to carbon dioxide,

lactic acid, ketones, ammonia, and other volatile organic compounds through our skin. Also noted in this meta study is that it's possible that diet can make you more attractive. And the two top culprits they found, beer and bananas, make you more delicious to mosquitoes or being pregnant. So according to the 2023 paper, prevalence of malaria parasite and its effects on some hematological parameters amongst pregnant women in Nigeria is

Pregnant people in the advanced stages of pregnancy exhale 21% more carbon dioxide than non-pregnant people, which makes them more

much more attractive to mosquitoes. And that's obviously a risk for both the baby and the parent. You do not want to get a disease from hungry mosquitoes. But yeah, while garlic through the skin will not repel these little vampires, your sweat, your microbes, and just simply breathing, breathing out carbon dioxide can be like a ring in dinner bell, like come and get it, to swarms of them.

I had a boyfriend once who was hiking in the Pacific Coast Trail years ago. And he said that they turned around and went home earlier because there were so many mosquitoes. And I was like, oh, I wonder if they're just breathing a lot. So they're looking for carbon dioxide. They're looking for...

certain things in your sweat as well? Yeah. So there's like chemical cues in our sweat that they're picking up. And that's why you've probably heard this, that certain blood types are more attractive to mosquitoes. And this is because every blood type has a chemical signature. And some...

based off a few papers, might be more attractive to mosquitoes than others. But I think at the end of the day, it really is the overall person and their biology at the time that might change depending on the mosquito species and the time and place. I love that you have done a deep dive on this. Have so many people asked you that you're... What caused you to start looking into these papers? I...

So I think early on it was like, I have type B blood. Does that make me more attractive? But at the end of the day, I was just like, but what is it about type B blood or whatever other blood types that are attractive?

to mosquitoes, like what is the biology behind that? Why is the blood actually attractive? For me, I think it is like a full scale picture of it's different indicators from that person, the CO2, chemical cues from the sweat, microbiota, or like the microbes in your sweat as well. They find that attractive. That is more of an indicator of if you're attractive to mosquitoes or not.

You just got your PhD, but you're already published on several papers. I saw about thermal sensitivity and microbes and thermal stress responses and temperature. What does temperature have to do with how mosquitoes either look for a blood meal or just exist?

Right. So I guess we'll frame this in the context of climate change. So climate change is going to influence mosquito population and disease transmission in several ways. And the first thing we think about is the expansion of mosquito habitats into new regions as temperatures rise and also the precipitation patterns.

Dr. Ware Gilmore says that altered seasonal patterns of mosquito activity can also lead to more transmission and longer transmission periods, also increased disease risk. So climate change isn't just water levels rising on seaside cottages, but you know that.

At the mosquito level, temperature can impact basically the growth rate and developmental rate of the mosquito, but also the rate of development for the pathogen inside of the mosquito. So we call this the extrinsic incubation period or the EIP. And EIP is the amount of time it takes for that pathogen to develop.

to traverse throughout the body of the mosquito and make it to the salivary glands where it then can be passed on when the mosquito is taking a new blood meal from an uninfected host.

Okay, so that extrinsic incubation period of malaria is also called the period of spirogyny, and it describes the time it takes for parasites to develop in the mosquito from the moment they take in comedocytes or sex cells via a tainted blood meal. And when they mate in their guts and travel to the salivary glands to be

splurted into your bloodstream. And according to Malaria Parasite Development in Mosquitoes, a 1998 journal article in the Annual Review of Entomology, Plasmodium vivax, one of the five species of the single-celled protozoa which causes malaria in humans, it takes just nine days from the ingestion to doing the nasty and mating in the mosquito tummy to taking up space in their salivary glands of the bug.

to get into you. So that extrinsic incubation period is important because it means you can be infected and malaria can spread before you've ever even shown symptoms or gotten treated to kill it. And so that pathogen lives in the salivary glands. Gross. Tell me more. And can you tell me a little bit about how the bites work? Is there a little bit of a blur of stuff into you?

Before they suck it back up? Are they spitting a little bit into you before they start sucking it up? Or are there anti-inflammatories? What does that needle mouth have? Yeah, so I guess we can look at the mosquito mouth part as six different needles. So you have two of them, which are going to be holding back the skin. One of them, which is actually doing the piercing and the sucking. And then you have actually two of them that are sawing at the skin. What? Fallon, what?

What? Yeah, they have this very specialized mouth part that is frightening when you look at pictures up close.

They have six beetles, including two saws. That's amazing. That makes Predator or like sci-fi monsters seem like so simple. Okay, two hold it open like a surgeon. Two to saw. Okay, what are the sawing ones doing? Well, I guess it's helping them kind of get through the skin to the capillaries, the blood vessels or the capillaries.

That's so cool. So we touched on some of the temperature work that I did previously. And I guess when we think about climate change, it's also just not risk of infection or increased mosquito bites based on the habitat you're in. But it's also the impact that it's going to have on the mosquito at an individual level. And so

The work I was doing before was looking at how infection with some of these pathogens alter the mosquito and its ability to cope with temperature and what that might mean for how we see the expansion of some of these mosquito ranges. Does it look like some of their numbers will reduce or are we looking at a huge increase?

Yeah, so it really depends on the mosquito species and the habitat and their prior thermal history. So in some areas, we expect a contraction of mosquito species, but in others, we expect that to expand and their geographical range to increase. But a lot of things have to fall in place for disease transmission to take place. So it's really species dependent.

When you were talking about the salivary glands, and then I absolutely lost my shit hearing that they have six different needles in their mouth. Yeah. Which that's like absolutely blowing my mind right now. Can you tell me more about that surgery that they perform? It sounds like laparoscopic surgery.

Yeah. So the first time I saw a mosquito mouth part, I was like, what is going on? What is this? Let's get into these twinkly, saw-mouthed, tiny little blood zombie fairies. So when a female mosquito pierces the skin, she has this, this basically this flexible lip-like sheath that goes up and it stays outside as the insect pushes in basically six needle-like parts. And so two

Two of these three needles are called the maxillae, and they have these tiny teeth that let the mosquitoes saw through human skin or through skin in general. And they're kind of like little drill bits. Yeah, they're so sharp we don't really feel the bite.

But they do enough damage. And then we have another set of needles, the mandibles that hold the tissue apart while the mosquito saws into the skin. And then the fifth needle is called the labrum and it pierces the blood vessel. Wow. Wow.

So they use some to spread it kind of like, like it just sounds like they're doing surgery. Yeah. I mean, they're surgeons. Yeah. And you have that fifth needle part that's piercing the blood vessel. It's looking for the blood vessel in that. So it's like moving around in the skin to find the blood vessel. Yeah.

My gosh. And then do they just do a poke into the blood vessel? And then is that kind of like a needle or is that also kind of like a saw? Like how are they piercing and sucking at the same time?

That is basically just piercing into the blood vessel and they're able to suck up with that appendage as well. The other two appendages have done basically the service of sawing. And then that last fifth needle, the labrum, is piercing but also sucking, the sucking mouth part. And of course, some mosquitoes fill up more than others. But the most common size mosquitoes are around six millimeters long and they weigh a few

milligrams at most, although they can drink two to three times their body weight at a time. And according to the Coachella Valley Mosquito and Vector Control District, mosquitoes can take in anywhere from 0.001 to 0.01 milliliters of blood. And their website says for its size, that would be the equivalent of a person drinking as much as is in a bathtub, says the Coachella Valley Mosquito and Vector Control District. Let me tell you something.

Coachella knows a little something about seasonal binge drinking. When we're talking about teen mosquitoes and big ones, do all of their mouthparts function kind of the same? So yeah, that proboscis and that piercing, sucking mouthpart is going to be the same for most of the species. It will change in size and the coloration might look different, but it serves the same purpose.

And when I picture a mosquito, I picture the ones that I probably grew up around and are more common to the West Coast of the United States. But how small and how big do they get?

Yeah. So our biggest species of mosquito is our elephant mosquito. So Toxorhynchides. And so this, he's a big fella. She's a big fella. But she, they have these tusks on them at the end of their proboscis, but they're, they're quite large mosquitoes. Not as large as crane flies, which people typically get confused with mosquitoes, but they are some of the larger of our mosquito species that we have.

And crane flies, they're not skeeter eaters, right? I thought forever, like, oh, those crane flies, don't worry, they eat mosquitoes. That's total horse pucky, right? Yeah. You know, it's okay because when I moved to Georgia with my family, the names for crane flies were so wild. It was like mosquito hawk, like hawk killer. And I was like, a hawk killer? I was like, what is that? But, you know, crane flies don't...

actually live that long either. They are using nectar as their main resource for energy, but they are not predators to mosquitoes. Or people, right? They're just trying to live their life. No, or people, you know, you kind of feel bad for them. Like they're not the most graceful flyers. Anytime I've seen a crane fly, they're like trying to make it to the door or the window. And then you just like have this random man in Walmart who's just like,

Kill that mosquito. And you're like, sir, that crane fly is just trying to live his best life. Like, let him go. He just wants to go find some fresh grass. He does. Like, their main job is to mate. Like, they're born. They're like, let me go find some sugar and then let me go mate and then die. They just want a snack and a date. Yeah.

He is all of us. All of us. So crane flies, neither mosquitoes nor mosquito assassins, just lonely, big, bumbling, mosquito-looking sugar lovers who might accidentally saunter clumsily into a big box store to get slandered and then killed.

So one of the big reasons I really enjoyed and was drawn to studying mosquitoes is because they're so diverse. And so as with most animals, size does matter. And like other groups, there's considerable size range of mosquito adults, even though they all look the same to us. And so I think the biggest difference that I've seen would probably be Uranotony and then

Toxorhynchides. So Toxorhynchides and galley nippers are quite large mosquitoes. And I think mass wise, between the smallest and the largest, it's maybe like a 60 fold mass difference. So quite, quite big. About the teeny ones, how teeny teeny do they get?

So I will say that I'm pretty biased because I work with a larger mosquito species. So Aedes mosquitoes in general are a little bit hardier, a little bit bigger than anophelines. But I will say that from my perspective, that anopheles species of mosquitoes tend to gear towards the smaller end compared to like an Aedes or a Culex mosquito. When it comes to mating and finding a date, how...

are mosquitoes finding each other? Is there natural selection or is it like this world is so big, I'm small, you're small, let's do it. I think, you know, it would be so fun to be like, is there a hinge for mosquitoes where they make like a profile picture? They're like, I'm from Alaska, but no, in all seriousness. So that buzzing noise that we find so

so irritating is actually emitted by mosquitoes and it's used for communication, but also mate location. And so male mosquitoes actually produce a higher frequency of sound versus females. And they're using that to locate and pursue a mate and potentially avoid threats and other predators.

Is there something evolutionarily about a really annoying noise that helps them mate? Or I wonder if you hear a high, high, high pitched annoying one, if that means it's a male and it's not going to bite you. Right. That's interesting. So for me, I think it

to do more with their morphology. And I think it's the way that their wings are set on their body. So I think they're able to produce that higher frequency sound because they are oscillating so quickly. And maybe that was just like something that was used as a signal for identifying potential mates. So apparently mosquitoes can flap their tiny little wings up to a thousand times a second at a tremendous

a tremendously high frequency, over 700 hertz, which is about the same pitch as a police siren, although it can vary depending on the mood they're trying to set. And according to some researchers at Cornell, male mosquitoes usually are thrumming a buzz around 600 to 700 hertz, and ladies are a bit lower at 400 hertz. But when they find each other and are about to mate, they are

quite literally vibing. They're raising their buzz frequency in harmonics to about 1200 hertz, which is right at like the whistle tone registers, like Mariah Carey's high notes. Just two bugs, just getting it on. And the males have these bushy antennae to pick up on ladies' locations using 7,000 sensory cells dedicated to hearing, which is almost as many as you have. Now, in case you're

you're like, this seems like something I could get into and you need a meditation playlist. Get yourself some inspo with this fresh as hell paper from last month. Surveillance of mosquitoes harnessing their buzzing sound, which concluded that yes, mosquito sounds are species specific and sex specific and important for communication. And they can even relay fed or unfed status. Cornell researcher, Dr. David Hoy has said, they are interacting on the fly and in song.

So they're kind of like hummingbirds that are surgeons a little bit. Yeah. Maybe. But that are also sparkly. They're also sparkly. You know, hummingbirds and mosquitoes...

Kind of. They're fast. They're kind of sparkly and they have that weird mouth part. Right. The tiniest hummingbirds ever. They just happen to like meat, which is you. Yeah. Some of them. Yeah. But we have one bazillion questions from listeners, which we were not going to toss at you all at once. But can I ask some from listeners? Yeah. Amazing. Okay.

So next week, we return with all the tips on how to repel them, what you can spray on your skin, what to do in your yard. We talk Zika, dengue, malaria, West Nile, how much to worry about each of them, and so many more practicalities that will make you itch and scratch a little less. Meanwhile, ask Mozzie people amazing questions because it's worth the wait. Now, you can follow Dr. Laura Gilmer on X at Mozzie Fowl, linked in the show notes. She's on Instagram at Foxy Fowl, which is also linked.

style and mosquito appreciation in equal measures. She's lovely. We'll be back next week with more of her wisdom and her bug facts and my personal giddiness. We're at Ologies on Instagram and Twitter. I'm at Ali Ward on both. Smologies is our new spinoff show in its own subscribable feed, Kid and Classroom Safe, Shorter Cuts of Classic Episodes. You can subscribe at the link in the show notes. That's Smologies. Please do tell friends with kids. Word of mouth is everything to us. So tell a friend.

Ologies merch is available at ologiesmerch.com. You can become a patron at patreon.com slash ologies. Our Ologies podcast Facebook group is admin by Erin Talbert. Professional transcripts by Aveline Malik of The Wordery. Noelle Dilworth is our scheduling producer. Susan Hale is our managing director who recently celebrated a birthday, even though she tends to lay low on her birthday. We love you, Susan. Deal with it. This episode was edited by Jake Chafee and lead editor who has earned her Scaly Mosquito Stripes.

Mercedes Maitland of Maitland Audio. Nick Thorburn wrote the theme music. And if you stick around to the end of the episode, I tell you a secret. And this week, I just realized that I said, tell a friend. And there was this grocery store chain. I must have been like three. And it was called Alpha Beta. And

Their commercials were like, Alpha Beta, tell a friend. And I took that very literally. And there was a friend of mine in the neighborhood named Tom, who was technically my first husband. We were three. We were set up. We had a ceremony. I actually scratched that. His name was Tad. I'm sorry about that, Tad. First husbands always get the shaft. But anyway, having been instructed by Alpha Beta via a commercial to please tell a friend, I was like, hey, Tad, Alpha Beta, I did it. And I hope he still remembers. But ologies.

Tell a friend. You can just say the word. You don't have to elaborate. I think either way, it's appreciated. But anyway. All right, that's it. Next week, more mosquitoes. How do you repel them? What do you do? What do you do? What do you do? Why? We got you. Bye-bye. It's just the mosquitoes. They love me.