#148 - Richard Miller, M.D., Ph.D.: The gold standard for testing longevity drugs: the Interventions Testing Program

Publish Date: 2021/2/8

The Peter Attia Drive

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#148 - Richard Miller, M.D., Ph.D.: The gold standard for testing longevity drugs: the Interventions Testing Program

The Peter Attia Drive

Chapters

How did Hayflick’s hypothesis impact aging research?

Can aging really be slowed?

What is the scientific framework of the Interventions Testing Program for longevity drugs?

What were the results of testing aspirin in the first ITP cohort?

Rapamycin: What do ITP studies reveal about its effects and dosing?

Acarbose: Could blocking peak glucose levels be a key to longevity?

Resveratrol: Why did it gain attention, and what do negative ITP results indicate?

The importance of negative findings: Lessons from green tea extract, methylene blue, and curcumin ITP studies

17α-Estradiol: What are the lifespan effects and sex-specific interventions in mice?

Testing ursolic acid and hydrogen sulfide: What were the rationales and preliminary results?

Canagliflozin: What impressive lifespan results were found in male mice?

Metformin: Why did it fail in ITP studies despite positive human data?

Nicotinamide riboside: Insights from its negative ITP results

What are the three most important takeaways from the ITP studies?

Philosophies on studying aging: Best model organisms and intervention timing

Seven reasons why pigs can't fly

Shownotes Transcript

PodQuest PodQuest Podcast Discovery Engine tailors playlist for your curiosity

#148 - Richard Miller, M.D., Ph.D.: The gold standard for testing longevity drugs: the Interventions Testing Program 02:14:14

The Peter Attia Drive

Chapters

How did Hayflick’s hypothesis impact aging research?

Can aging really be slowed?

What is the scientific framework of the Interventions Testing Program for longevity drugs?

What were the results of testing aspirin in the first ITP cohort?

Rapamycin: What do ITP studies reveal about its effects and dosing?

Acarbose: Could blocking peak glucose levels be a key to longevity?

Resveratrol: Why did it gain attention, and what do negative ITP results indicate?

The importance of negative findings: Lessons from green tea extract, methylene blue, and curcumin ITP studies

17α-Estradiol: What are the lifespan effects and sex-specific interventions in mice?

Testing ursolic acid and hydrogen sulfide: What were the rationales and preliminary results?

Canagliflozin: What impressive lifespan results were found in male mice?

Metformin: Why did it fail in ITP studies despite positive human data?

Nicotinamide riboside: Insights from its negative ITP results

What are the three most important takeaways from the ITP studies?

Philosophies on studying aging: Best model organisms and intervention timing

Seven reasons why pigs can't fly

Shownotes Transcript

PodQuest PodQuest Podcast Discovery Engine tailors playlist for your curiosity

#148 - Richard Miller, M.D., Ph.D.: The gold standard for testing longevity drugs: the Interventions Testing Program